Anti-RAMP3 Antibody

Rs. 45,619.00
SKU stj28798

General Information

Product name Anti-RAMP3 Antibody
Short Description Rabbit polyclonal to RAMP3
Description The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:10 - 1:100
Protein Name Anti-RAMP3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RAMP3 (NP_005847.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 16.5 kDa
Database Links
Alternative Names RAMP3Receptor activity-modifying protein 3 antibodyCalcitonin-receptor-like receptor activity-modifying protein 3 antibodyCRLR activity-modifying protein 3RAMP3
Function Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner, Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane, Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Cellular Localization Cell membrane.
Tissue Specificity Strongly expressed in lung, breast, immune system and fetal tissues.
Swiss-Prot Key

 

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