Anti-RARA Antibody

Rs. 45,619.00
SKU stj26160

General Information

Product name Anti-RARA Antibody
Short Description Rabbit polyclonal to RARA
Description This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Anti-RARA Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-457 of human RARA (NP_001019980.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 50.8 kDa
Database Links
Alternative Names RARARetinoic acid receptor alpha antibodyRAR-alpha antibodyNuclear receptor subfamily 1 group B member 1RARA antibodyNR1B1
Function Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression, On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation, RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis, Has a role in the survival of early spermatocytes at the beginning prophase of meiosis, In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes, In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF