Anti-RFFL Antibody

Rs. 45,619.00
SKU stj28572

General Information

Product name Anti-RFFL Antibody
Short Description Rabbit polyclonal to RFFL
Description
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-RFFL Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 40.5 kDa
Database Links
Alternative Names RFFLE3 ubiquitin-protein ligase rififylin RFFL antibodyRNF189 antibodyRNF34L
Function E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex, Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis, Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation, Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation, Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN, May also play a role in endocytic recycling.
Cellular Localization Cytoplasm, cytosol, Cell membrane
Tissue Specificity Ubiquitous, detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Swiss-Prot Key

 

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