Anti-RNF20 Antibody

Rs. 61,689.00
SKU stj25372

General Information

Product name Anti-RNF20 Antibody
Short Description Mouse monoclonal to RNF20
Description The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Applications WB
Dilution range WB 1:200 - 1:500
Protein Name Anti-RNF20 Antibody
Immunogen A synthetic peptide of human RNF20
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 113.7 kDa
Database Links
Alternative Names RNF20E3 ubiquitin-protein ligase BRE1A antibodyBRE1-A antibodyhBRE1RNF20 antibodyBRE1A
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively), It thereby plays a central role inb histone code and gene regulation, The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B
Cellular Localization Nucleus
Tissue Specificity Expressed in the normal brain and also in malignant gliomas (at protein level).
Swiss-Prot Key

 

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