Anti-RNF7 Antibody

Rs. 45,619.00
SKU stj29440

General Information

Product name Anti-RNF7 Antibody
Short Description Rabbit polyclonal to RNF7
Description The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:20 - 1:50
Protein Name Anti-RNF7 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human RNF7 (NP_055060.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 12.7 kDa
Database Links
Alternative Names RNF7RING-box protein 2 antibodyRbx2 antibodyCKII beta-binding protein 1 antibodyCKBBP1 antibodyRING finger protein 7 antibodyRegulator of cullins 2 antibodySensitive to apoptosis gene proteinRNF7 antibodyRBX2 antibodyROC2 antibodySAG
Function Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription , Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate, Promotes the neddylation of CUL5 via its interaction with UBE2F, May play a role in protecting cells from apoptosis induced by redox agents.
Cellular Localization Cytoplasm
Tissue Specificity Expressed in heart, liver, skeletal muscle and pancreas, at very low levels expressed in brain, placenta and lung.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF