Anti-RRAGA Antibody

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Rs. 34,800.00
Rs. 32,800.00
SKU stj110082

General Information

Product name Anti-RRAGA Antibody
Short Description Rabbit polyclonal to RRAGA
Description
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Ras-related GTP-binding protein ARag ARagAAdenovirus E3 14.7 kDa-interacting protein 1FIP-1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human RRAGA (NP_006561.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.6 kDa
Database Links
Alternative Names RRAGARas-related GTP-binding protein A antibodyRag A antibodyRagA antibodyAdenovirus E3 14.7 kDa-interacting protein 1 antibodyFIP-1RRAGA
Function Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade, Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form, In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB, Involved in the RCC1/Ran-GTPase pathway, May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death, May alternatively act as a cellular target for adenovirus E3-14,7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Cellular Localization Cytoplasm.
Tissue Specificity Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Swiss-Prot Key

 

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