Anti-RUNX3 Antibody

Rs. 45,619.00
SKU stj29442

General Information

Product name Anti-RUNX3 Antibody
Short Description Rabbit polyclonal to RUNX3
Description This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-RUNX3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 210-429 of human RUNX3 (NP_001026850.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 44.4 kDa
Database Links
Alternative Names RUNX3Runt-related transcription factor 3 antibodyAcute myeloid leukemia 2 protein antibodyCore-binding factor subunit alpha-3 antibodyCBF-alpha-3 antibodyOncogene AML-2 antibodyPolyomavirus enhancer-binding protein 2 alpha C subunit antibodyPEA2-alpha C antibodyPEBP2-alpha C antibodySL3-3 enhancer factor 1 alpha C subunit antibodySL3/AKV core-binding factor alpha C subunitRUNX3 antibodyAML2 antibodyCBFA3 antibodyPEBP2A3
Function Forms the heterodimeric complex core-binding factor (CBF) with CBFB, RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX, The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity), May be involved in the control of cellular proliferation and/or differentiation, In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation.
Cellular Localization Nucleus
Tissue Specificity Expressed in gastric cancer tissues (at protein level).
Swiss-Prot Key

 

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