Anti-RYR2 Antibody

Rs. 45,619.00
SKU stj25428

General Information

Product name Anti-RYR2 Antibody
Short Description Rabbit polyclonal to RYR2
Description This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-RYR2 Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1950-2050 of human RYR2 (NP_001026.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 564.6 kDa
Database Links
Alternative Names RYR2Ryanodine receptor 2 antibodyRYR-2 antibodyRyR2 antibodyhRYR-2 antibodyCardiac muscle ryanodine receptor antibodyCardiac muscle ryanodine receptor-calcium release channel antibodyType 2 ryanodine receptorRYR2
Function Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction, Aberrant channel activation can lead to cardiac arrhythmia, In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C, The calcium channel activity is modulated by formation of heterotetramers with RYR3, Required for cellular calcium ion homeostasis, Required for embryonic heart development.
Cellular Localization Sarcoplasmic reticulum membrane
Tissue Specificity Detected in heart muscle (at protein level), heart muscle, brain (cerebellum and hippocampus) and placenta.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF