Anti-S100A9 Antibody

Rs. 68,577.00
SKU stj71826

General Information

Product name Anti-S100A9 Antibody
Short Description Goat polyclonal to S100A9
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-S100A9 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 13.2 kDa
Database Links
Alternative Names S100A9Protein S100-A9 antibodyCalgranulin-B antibodyCalprotectin L1H subunit antibodyLeukocyte L1 complex heavy chain antibodyMigration inhibitory factor-related protein 14 antibodyMRP-14 antibodyp14 antibodyS100 calcium-binding protein A9S100A9 antibodyCAGB antibodyCFAG antibodyMRP14
Function S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response, It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism, Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions, The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase, Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX, The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities, Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration, Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER), Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade, Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth, Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3, Can regulate neutrophil number and apoptosis by an anti-apoptotic effect
Cellular Localization Secreted, Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane
Tissue Specificity Calprotectin (s100a8/9) is predominantly expressed in myeloid cells, except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes, under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis, found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, crohn's disease, giant cell arteritis, cystic fibrosis, sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis, involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions, strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers,
Swiss-Prot Key

 

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