Anti-SENP6 Antibody

Rs. 68,577.00
SKU stj71464

General Information

Product name Anti-SENP6 Antibody
Short Description Goat polyclonal to SENP6
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-SENP6 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 126.1 kDa
Database Links
Alternative Names SENP6Sentrin-specific protease 6 SENP6 antibodyKIAA0797 antibodySSP1 antibodySUSP1 antibodyFKSG6
Function Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins, Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors, Deconjugates SUMO1 from RXRA, leading to transcriptional activation, Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex, Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation, Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination,
Cellular Localization Nucleus
Tissue Specificity Highly expressed in reproductive organs, such as testis, ovary and prostate
Swiss-Prot Key

 

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