Anti-SH2D1A Antibody

Rs. 68,577.00
SKU stj70732

General Information

Product name Anti-SH2D1A Antibody
Short Description Goat polyclonal to SH2D1A
Description
Applications ELISA, WB, IP
Dilution range
Protein Name Anti-SH2D1A Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 14.2 kDa
Database Links
Alternative Names SH2D1ASH2 domain-containing protein 1A antibodyDuncan disease SH2-protein antibodySignaling lymphocytic activation molecule-associated protein antibodySLAM-associated protein antibodyT-cell signal transduction molecule SAPSH2D1A antibodyDSHP antibodySAP
Function Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7, In SLAM signaling seems to cooperate with SH2D1B/EAT-2, Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 , May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3,
Cellular Localization Cytoplasm
Tissue Specificity Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver, expressed in peripheral blood leukocytes, including t-lymphocytes, tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis,
Swiss-Prot Key

 

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