Anti-SIAH1 Antibody (Biotin)

Rs. 68,577.00
SKU stj73231

General Information

Product name Anti-SIAH1 Antibody (Biotin)
Short Description Goat polyclonal to SIAH1 (Biotin)
Applications ELISA, WB, IP
Dilution range
Protein Name Anti-SIAH1 Antibody (Biotin)
Immunogen N Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Conjugation Biotin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.


Gene ID
Gene Symbol
Molecular Weight 31.1 kDa
Database Links
Alternative Names SIAH1E3 ubiquitin-protein ligase SIAH1 SIAH1 antibodyHUMSIAH
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes, Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP, Confers constitutive instability to HIPK2 through proteasomal degradation, It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling, Has some overlapping function with SIAH2, Induces apoptosis in cooperation with PEG3, Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus, GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins,
Cellular Localization Cytoplasm, Nucleus,
Tissue Specificity Widely expressed at a low level, down-regulated in advanced hepatocellular carcinomas,
Swiss-Prot Key


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