Anti-SIGLEC5 Antibody

Rs. 50,211.00
SKU stj26591

General Information

Product name Anti-SIGLEC5 Antibody
Short Description Rabbit polyclonal to SIGLEC5
Description This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-SIGLEC5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 452-551 of human SIGLEC5 (NP_003821.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.7 kDa
Database Links
Alternative Names SIGLEC5Sialic acid-binding Ig-like lectin 5 antibodySiglec-5 antibodyCD33 antigen-like 2 antibodyObesity-binding protein 2 antibodyOB-BP2 antibodyOB-binding protein 2 antibodyCD antigen CD170SIGLEC5 antibodyCD33L2 antibodyOBBP2
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
Cellular Localization Membrane
Tissue Specificity Expressed by monocytic/myeloid lineage cells, found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus, expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation
Swiss-Prot Key

 

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