Anti-SIRT4 Antibody

Rs. 45,619.00
SKU stj29722

General Information

Product name Anti-SIRT4 Antibody
Short Description Rabbit polyclonal to SIRT4
Description This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-SIRT4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 29-260 of human SIRT4 (NP_036372.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 35.2 kDa
Database Links
Alternative Names SIRT4NAD-dependent protein lipoamidase sirtuin-4 antibodymitochondrial SIRT4 antibodySIR2L4
Function Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase, Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications, Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner , Down-regulates insulin secretion.
Cellular Localization Mitochondrion matrix
Tissue Specificity Detected in vascular smooth muscle and striated muscle, detected in insulin-producing beta-cells in pancreas islets of langerhans (at protein level), widely expressed, weakly expressed in leukocytes and fetal thymus.
Swiss-Prot Key

 

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