Anti-SKP1 Antibody

Rs. 61,689.00
SKU stj25540

General Information

Product name Anti-SKP1 Antibody
Short Description Rabbit polyclonal to SKP1
Description This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-SKP1 Antibody
Immunogen A synthetic peptide of human SKP1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 18.7 kDa
Database Links
Alternative Names SKP1S-phase kinase-associated protein 1 antibodyCyclin-A/CDK2-associated protein p19 antibodyp19A antibodyOrgan of Corti protein 2 antibodyOCP-2 antibodyOrgan of Corti protein II antibodyOCP-II antibodyRNA polymerase II elongation factor-like protein antibodySIII antibodyTranscription elongation factor B polypeptide 1-like antibodyp19skp1SKP1 antibodyEMC19 antibodyOCP2 antibodySKP1A antibodyTCEB1L
Function Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription, In the SCF complex, serves as an adapter that links the F-box protein to CUL1, The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component, SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling, SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA, SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 directs ubiquitination of BCL2.
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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