Anti-SLC7A5 Antibody

Rs. 68,577.00
SKU stj71879

General Information

Product name Anti-SLC7A5 Antibody
Short Description Goat polyclonal to SLC7A5
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-SLC7A5 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 55 kDa
Database Links
Alternative Names SLC7A5Large neutral amino acids transporter small subunit 1 antibody4F2 light chain antibody4F2 LC antibody4F2LC antibodyCD98 light chain antibodyIntegral membrane protein E16 antibodyL-type amino acid transporter 1 antibodyhLAT1 antibodySolute carrier family 7 member 5 antibodyy+ system cationic amino acid transporterSLC7A5 antibodyCD98LC antibodyLAT1 antibodyMPE16
Function Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc, Involved in cellular amino acid uptake, Acts as an amino acid exchanger, Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta, Plays a role in neuronal cell proliferation (neurogenesis) in brain, Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity, Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane, May play an important role in high-grade gliomas, Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina, Acts as the major transporter of tyrosine in fibroblasts, When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation ,
Cellular Localization Cytoplasm, cytosol, Apical cell membrane
Tissue Specificity Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver, weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node, during gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage, also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas, expressed in retinal endothelial cells and in the intestinal epithelial cell line caco-2,
Swiss-Prot Key

 

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