Anti-SOCS1 Antibody (Biotin)

Rs. 68,577.00
SKU stj73272

General Information

Product name Anti-SOCS1 Antibody (Biotin)
Short Description Goat polyclonal to SOCS1 (Biotin)
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-SOCS1 Antibody (Biotin)
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Biotin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 23.6 kDa
Database Links
Alternative Names SOCS1Suppressor of cytokine signaling 1 antibodySOCS-1 antibodyJAK-binding protein antibodyJAB antibodySTAT-induced STAT inhibitor 1 antibodySSI-1 antibodyTec-interacting protein 3 antibodyTIP-3SOCS1 antibodySSI1 antibodyTIP3
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction, SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway, Through binding to JAKs, inhibits their kinase activity, In vitro, also suppresses Tec protein-tyrosine activity, Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF), Regulates interferon-gamma mediated sensory neuron survival (By similarity), Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Seems to recognize JAK2, SOCS1 appears to be a negative regulator in IGF1R signaling pathway,
Cellular Localization Nucleus,
Tissue Specificity Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes
Swiss-Prot Key

 

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