Anti-STAT5A Antibody

Rs. 61,689.00
SKU stj25722

General Information

Product name Anti-STAT5A Antibody
Short Description Rabbit polyclonal to STAT5A
Description The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-STAT5A Antibody
Immunogen A synthetic peptide of human STAT5A
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 90.6 kDa
Database Links
Alternative Names STAT5ASignal transducer and activator of transcription 5ASTAT5A antibodySTAT5
Function Carries out a dual function: signal transduction and activation of transcription, Mediates cellular responses to the cytokine KITLG/SCF and other growth factors, Mediates cellular responses to ERBB4, May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4, Binds to the GAS element and activates PRL-induced transcription, Regulates the expression of milk proteins during lactation.
Cellular Localization Cytoplasm.
Tissue Specificity
Swiss-Prot Key

 

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