Anti-AAK1 Antibody

Rs. 68,577.00
SKU stj72034

General Information

Product name Anti-AAK1 Antibody
Short Description Goat polyclonal to AAK1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-AAK1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 103.9 kDa
Database Links
Alternative Names AAK1AP2-associated protein kinase 1 AAK1 antibodyKIAA1048
Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis, Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1, Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes, Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes, Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity,
Cellular Localization Cell membrane,
Tissue Specificity Detected in brain, heart and liver, isoform 1 is the predominant isoform in brain,
Swiss-Prot Key

 

You recently viewed

Clear recently viewed