Anti-SUFU Antibody

Rs. 45,619.00
SKU stj28840

General Information

Product name Anti-SUFU Antibody
Short Description Rabbit polyclonal to SUFU
Description The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-SUFU Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 325-484 of human SUFU (NP_057253.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 53.9 kDa
Database Links
Alternative Names SUFUSuppressor of fused homolog antibodySUFUHSUFU antibodyUNQ650/PRO1280
Function Negative regulator in the hedgehog/smoothened signaling pathway, Down-regulates GLI1-mediated transactivation of target genes.
Cellular Localization Cytoplasm
Tissue Specificity Ubiquitous in adult tissues, detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos, isoform 1 is detected in fetal brain, lung, kidney and testis, isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney.
Swiss-Prot Key

 

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