Anti-SUV39H2 Antibody

Rs. 68,577.00
SKU stj70283

General Information

Product name Anti-SUV39H2 Antibody
Short Description Goat polyclonal to SUV39H2
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-SUV39H2 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 46.7 kDa
Database Links
Alternative Names SUV39H2Histone-lysine N-methyltransferase SUV39H2 SUV39H2 antibodyKMT1B
Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate, H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones, Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions, H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats, SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length, May participate in regulation of higher-order chromatin organization during spermatogenesis, Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation,
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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