Anti-C8orf4 Antibody

Rs. 45,619.00
SKU stj29940

General Information

Product name Anti-C8orf4 Antibody
Short Description Rabbit polyclonal to TCIM
Description This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-C8orf4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 12.3 kDa
Database Links
Alternative Names TCIMTranscriptional and immune response regulator antibodyThyroid cancer protein 1 antibodyTC-1TCIM antibodyC8orf4 antibodyTC1
Function Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type, May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1.
Cellular Localization Cytoplasm.
Tissue Specificity Ubiquitous, expressed in thyroid papillary carcinoma, expressed in liver, expression levels decrease in hepatocellular carcinoma.
Swiss-Prot Key

 

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