Anti-TEAD1 Antibody

Rs. 45,619.00
SKU stj28851

General Information

Product name Anti-TEAD1 Antibody
Short Description Rabbit polyclonal to TEAD1
Description This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified.
Applications WB,IF,ChIP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
ChIP 1:50 - 1:200
Protein Name Anti-TEAD1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 135-215 of human TEAD1 (NP_068780.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 47.9 kDa
Database Links
Alternative Names TEAD1Transcriptional enhancer factor TEF-1 antibodyNTEF-1 antibodyProtein GT-IIC antibodyTEA domain family member 1 antibodyTEAD-1 antibodyTranscription factor 13 antibodyTCF-13TEAD1 antibodyTCF13 antibodyTEF1
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction, Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner, The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF), Involved in cardiac development, Binds to the M-CAT motif.
Cellular Localization Nucleus
Tissue Specificity Preferentially expressed in skeletal muscle, lower levels in pancreas, placenta, and heart
Swiss-Prot Key

 

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