Anti-TFPI Antibody

Rs. 45,619.00
SKU stj25826

General Information

Product name Anti-TFPI Antibody
Short Description Rabbit polyclonal to TFPI
Description This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-TFPI Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 29-224 of human TFPI (NP_001027452.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 35 kDa
Database Links
Alternative Names TFPITissue factor pathway inhibitor antibodyTFPI antibodyExtrinsic pathway inhibitor antibodyEPI antibodyLipoprotein-associated coagulation inhibitor antibodyLACITFPI antibodyLACI antibodyTFPI1
Function Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex, It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma
Cellular Localization Isoform Alpha: Secreted
Tissue Specificity Mostly in endothelial cells
Swiss-Prot Key

 

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