Anti-THBD Antibody

Rs. 45,619.00
SKU stj25842

General Information

Product name Anti-THBD Antibody
Short Description Rabbit polyclonal to THBD
Description The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Anti-THBD Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human THBD (NP_000352.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.3 kDa
Database Links
Alternative Names THBDThrombomodulin antibodyTM antibodyFetomodulin antibodyCD antigen CD141THBD antibodyTHRM
Function Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin, This complex is responsible for the conversion of protein C to the activated protein C (protein Ca), Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated
Cellular Localization Membrane
Tissue Specificity Endothelial cells are unique in synthesizing thrombomodulin
Swiss-Prot Key

 

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