Anti-TICAM1 Antibody

Rs. 45,619.00
SKU stj25850

General Information

Product name Anti-TICAM1 Antibody
Short Description Rabbit polyclonal to TICAM1
Description This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-TICAM1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human TICAM1 (NP_891549.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 76.4 kDa
Database Links
Alternative Names TICAM1TIR domain-containing adapter molecule 1 antibodyTICAM-1 antibodyProline-rich antibodyvinculin and TIR domain-containing protein B antibodyPutative NF-kappa-B-activating protein 502H antibodyToll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta antibodyMyD88-3 antibodyTIR domain-containing adapter protein inducing IFN-betaTICAM1 antibodyPRVTIRB antibodyTRIF
Function Involved in innate immunity against invading pathogens, Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis, Ligand binding to these receptors results in TRIF recruitment through its TIR domain, Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Cellular Localization Cytoplasmic vesicle, autophagosome
Tissue Specificity Ubiquitously expressed but with higher levels in liver.
Swiss-Prot Key

 

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