Anti-TICAM1 Antibody

Rs. 68,577.00
SKU stj73134

General Information

Product name Anti-TICAM1 Antibody
Short Description Goat polyclonal to TICAM1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-TICAM1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 76.4 kDa
Database Links
Alternative Names TICAM1TIR domain-containing adapter molecule 1 antibodyTICAM-1 antibodyProline-rich antibodyvinculin and TIR domain-containing protein B antibodyPutative NF-kappa-B-activating protein 502H antibodyToll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta antibodyMyD88-3 antibodyTIR domain-containing adapter protein inducing IFN-betaTICAM1 antibodyPRVTIRB antibodyTRIF
Function Involved in innate immunity against invading pathogens, Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis, Ligand binding to these receptors results in TRIF recruitment through its TIR domain, Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively, Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity),
Cellular Localization Cytoplasmic vesicle, autophagosome,
Tissue Specificity Ubiquitously expressed but with higher levels in liver,
Swiss-Prot Key

 

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