Anti-TLR2 Antibody

Rs. 57,098.00
SKU stj29799

General Information

Product name Anti-TLR2 Antibody
Short Description Rabbit polyclonal to TLR2
Description The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
Applications WB,ICC,IP
Dilution range WB 1:500 - 1:2000
ICC 1:50 - 1:200
IP 1:20 - 1:50
Protein Name Anti-TLR2 Antibody
Immunogen Recombinant protein of human TLR2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 89.8 kDa
Database Links
Alternative Names TLR2Toll-like receptor 2 antibodyToll/interleukin-1 receptor-like protein 4 antibodyCD antigen CD282TLR2 antibodyTIL4
Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components, Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.
Cellular Localization Membrane
Tissue Specificity Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen, also detected in lung and in fetal liver, levels are low in other tissues
Swiss-Prot Key

 

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