Anti-TNFAIP3 Antibody

Rs. 45,619.00
SKU stj25884

General Information

Product name Anti-TNFAIP3 Antibody
Short Description Rabbit polyclonal to TNFAIP3
Description This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-TNFAIP3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TNFAIP3 (NP_006281.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 89.6 kDa
Database Links
Alternative Names TNFAIP3Tumor necrosis factor alpha-induced protein 3 antibodyTNF alpha-induced protein 3TNFAIP3 antibodyOTUD7C
Function Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity, Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways
Cellular Localization Cytoplasm, Nucleus, Lysosome
Tissue Specificity
Swiss-Prot Key

 

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