General Information
Product name | Anti-TNFRSF13B Antibody |
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Short Description | Rabbit polyclonal to TNFRSF13B |
Description | The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. |
Applications | WB,IHC |
Dilution range | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Protein Name | Anti-TNFRSF13B Antibody |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 184-293 of human TNFRSF13B (NP_036584.1). |
Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
Type of Usage | For Research Use Only (RUO). |
Product Properties
Host | Rabbit |
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Clonality | Polyclonal |
Reactivity | |
Conjugation | Unconjugated |
Purification | Affinity purification |
Isotype | IgG |
Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
Gene ID | |
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Gene Symbol | |
Molecular Weight | 31.8 kDa |
Database Links | |
Alternative Names | TNFRSF13BTumor necrosis factor receptor superfamily member 13B antibodyTransmembrane activator and CAML interactor antibodyCD antigen CD267TNFRSF13B antibodyTACI |
Function | Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity, Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1, Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. |
Cellular Localization | Membrane |
Tissue Specificity | Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes, expressed in resting b-cells and activated t-cells, but not in resting t-cells |
Swiss-Prot Key |