General Information
| Product name | Anti-TNFRSF13B Antibody |
|---|---|
| Short Description | Rabbit polyclonal to TNFRSF13B |
| Description | The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. |
| Applications | WB,IHC |
| Dilution range | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Protein Name | Anti-TNFRSF13B Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 184-293 of human TNFRSF13B (NP_036584.1). |
| Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgG |
| Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 31.8 kDa |
| Database Links | |
| Alternative Names | TNFRSF13BTumor necrosis factor receptor superfamily member 13B antibodyTransmembrane activator and CAML interactor antibodyCD antigen CD267TNFRSF13B antibodyTACI |
| Function | Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity, Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1, Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. |
| Cellular Localization | Membrane |
| Tissue Specificity | Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes, expressed in resting b-cells and activated t-cells, but not in resting t-cells |
| Swiss-Prot Key |
