Anti-TNFSF11 Antibody

Rs. 45,619.00
SKU stj25900

General Information

Product name Anti-TNFSF11 Antibody
Short Description Rabbit polyclonal to TNFSF11
Description This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-TNFSF11 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 78-317 of human TNFSF11 (NP_003692.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 35.5 kDa
Database Links
Alternative Names TNFSF11Tumor necrosis factor ligand superfamily member 11 antibodyOsteoclast differentiation factor antibodyODF antibodyOsteoprotegerin ligand antibodyOPGL antibodyReceptor activator of nuclear factor kappa-B ligand antibodyRANKL antibodyTNF-related activation-induced cytokine antibodyTRANCE antibodyCD antigen CD254TNFSF11 antibodyOPGL antibodyRANKL antibodyTRANCE
Function Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK, Osteoclast differentiation and activation factor, Augments the ability of dendritic cells to stimulate naive T-cell proliferation, May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response, May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Cellular Localization Cell membrane
Tissue Specificity Highest in the peripheral lymph nodes, weak in spleen, peripheral blood leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid
Swiss-Prot Key

 

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