Anti-TP53 Antibody

Rs. 45,619.00
SKU stj25927

General Information

Product name Anti-TP53 Antibody
Short Description Rabbit polyclonal to TP53
Description This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-TP53 Antibody
Immunogen Recombinant protein of human TP53
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 43.7 kDa
Database Links
Alternative Names TP53Cellular tumor antigen p53 antibodyAntigen NY-CO-13 antibodyPhosphoprotein p53 antibodyTumor suppressor p53TP53 antibodyP53
Function Acts as a tumor suppressor in many tumor types
Cellular Localization Cytoplasm, Nucleus, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoplasm
Tissue Specificity Ubiquitous, isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner, isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver, isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver, isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast, isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine, isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
Swiss-Prot Key

 

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