Anti-TREX1 Antibody

Rs. 45,619.00
SKU stj28861

General Information

Product name Anti-TREX1 Antibody
Short Description Rabbit polyclonal to TREX1
Description This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-TREX1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TREX1 (NP_057465.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.2 kDa
Database Links
Alternative Names TREX1Three-prime repair exonuclease 1 TREX1
Function Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini, Prevents cell-intrinsic initiation of autoimmunity, Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements, Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling, Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates, Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light, During GZMA-mediated cell death, contributes to DNA damage in concert with NME1, NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Cellular Localization Nucleus, Cytoplasm, cytosol, Endoplasmic reticulum membrane
Tissue Specificity Detected in thymus, spleen, liver, brain, heart, small intestine and colon.
Swiss-Prot Key

 

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