Anti-TRIM28 Antibody

Rs. 68,577.00
SKU stj73296

General Information

Product name Anti-TRIM28 Antibody
Short Description Goat polyclonal to TRIM28
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-TRIM28 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 88.5 kDa
Database Links
Alternative Names TRIM28Transcription intermediary factor 1-beta antibodyTIF1-beta antibodyE3 SUMO-protein ligase TRIM28TRIM28 antibodyKAP1 antibodyRNF96 antibodyTIF1B
Function Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs), Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression, Recruitment of SETDB1 induces heterochromatinization, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, Also corepressor for ERBB4, Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Important regulator of CDKN1A/p21(CIP1), Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity, Ubiquitinates p53/TP53 leading to its proteosomal degradation
Cellular Localization Nucleus
Tissue Specificity Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes,
Swiss-Prot Key

 

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