Anti-TRIM29 Antibody

Rs. 45,619.00
SKU stj29644

General Information

Product name Anti-TRIM29 Antibody
Short Description Rabbit polyclonal to TRIM29
Description The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-TRIM29 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 309-588 of human TRIM29 (NP_036233.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 65.8 kDa
Database Links
Alternative Names TRIM29Tripartite motif-containing protein 29 antibodyAtaxia telangiectasia group D-associated proteinTRIM29 antibodyATDC
Function Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract, Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation, In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited, Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in placenta, prostate and thymus.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF