Anti-ULK3 Antibody

Rs. 68,577.00
SKU stj72686

General Information

Product name Anti-ULK3 Antibody
Short Description Goat polyclonal to ULK3
Description
Applications ELISA
Dilution range
Protein Name Anti-ULK3 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 53.4 kDa
Database Links
Alternative Names ULK3Serine/threonine-protein kinase ULK3 ULK3
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy, Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3), Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation, Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently, Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy,
Cellular Localization Cytoplasm,
Tissue Specificity Widely expressed, highest levels observed in fetal brain, in adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta, in the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve, in the central nervous system, lowest levels in the spinal cord,
Swiss-Prot Key

 

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