Anti-UPF3A Antibody

Rs. 57,098.00
SKU stj72041

General Information

Product name Anti-UPF3A Antibody
Short Description Goat polyclonal to UPF3A
Description
Applications ELISA
Dilution range
Protein Name Anti-UPF3A Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 54.7 kDa
Database Links
Alternative Names UPF3ARegulator of nonsense transcripts 3A antibodyNonsense mRNA reducing factor 3A antibodyUp-frameshift suppressor 3 homolog A antibodyhUpf3UPF3A antibodyRENT3A antibodyUPF3
Function Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery, Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD, However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B, Binds spliced mRNA upstream of exon-exon junctions, In vitro, weakly stimulates translation,
Cellular Localization Nucleus, Cytoplasm,
Tissue Specificity Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord, isoform 2 is strongly expressed in fetal brain and spinal cord,
Swiss-Prot Key

 

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