Anti-VAV1 Antibody

Rs. 61,689.00
SKU stj26073

General Information

Product name Anti-VAV1 Antibody
Short Description Mouse monoclonal to VAV1
Description This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-VAV1 Antibody
Immunogen Recombinant protein of human VAV1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 98.3 kDa
Database Links
Alternative Names VAV1Proto-oncogene vavVAV1 antibodyVAV
Function Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation
Cellular Localization
Tissue Specificity Widely expressed in hematopoietic cells but not in other cell types
Swiss-Prot Key

 

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