Anti-VEGFA Antibody

Rs. 45,619.00
SKU stj27525

General Information

Product name Anti-VEGFA Antibody
Short Description Rabbit polyclonal to VEGFA
Description This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
Applications WB,IF,IP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
IP 1:50 - 1:100
Protein Name Anti-VEGFA Antibody
Immunogen A synthetic peptide of human VEGFA
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 27 kDa
Database Links
Alternative Names VEGFAVascular endothelial growth factor A antibodyVEGF-A antibodyVascular permeability factor antibodyVPFVEGFA antibodyVEGF
Function Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth, Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels, Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin, NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145, Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth, Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Cellular Localization Secreted.
Tissue Specificity Isoform vegf189, isoform vegf165 and isoform vegf121 are widely expressed, isoform vegf206 and isoform vegf145 are not widely expressed, a higher level expression seen in pituitary tumors as compared to the pituitary gland.
Swiss-Prot Key

 

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