Anti-VTI1A Antibody

Rs. 45,619.00
SKU stj27141

General Information

Product name Anti-VTI1A Antibody
Short Description Rabbit polyclonal to VTI1A
Description The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-VTI1A Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human VTI1A (NP_660207.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 25.2 kDa
Database Links
Alternative Names VTI1AVesicle transport through interaction with t-SNAREs homolog 1A antibodyVesicle transport v-SNARE protein Vti1-like 2 antibodyVti1-rp2VTI1A
Function V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane, These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers, Involved in vesicular transport from the late endosomes to the trans-Golgi network, Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2, May be involved in increased cytokine secretion associated with cellular senescence.
Cellular Localization Cytoplasmic vesicle
Tissue Specificity
Swiss-Prot Key

 

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