Anti-WISP1 Antibody

Rs. 45,619.00
SKU stj26112

General Information

Product name Anti-WISP1 Antibody
Short Description Rabbit polyclonal to WISP1
Description This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-WISP1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 158-367 of human WISP1 (NP_003873.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 40.3 kDa
Database Links
Alternative Names WISP1WNT1-inducible-signaling pathway protein 1 antibodyWISP-1 antibodyCCN family member 4 antibodyWnt-1-induced secreted proteinWISP1 antibodyCCN4
Function Downstream regulator in the Wnt/Frizzled-signaling pathway, Associated with cell survival, Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase, Up-regulates the anti-apoptotic Bcl-X(L) protein, Adheres to skin and melanoma fibroblasts, In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
Cellular Localization Secreted
Tissue Specificity Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen, isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta, overexpression is associated with several cancers including breast cancer and colon tumors, isoform 2 is overexpressed in scirrhous gastric carcinoma
Swiss-Prot Key

 

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