Anti-XPO5 Antibody

Rs. 45,619.00
SKU stj28873

General Information

Product name Anti-XPO5 Antibody
Short Description Rabbit polyclonal to XPO5
Description This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.
Applications WB,IHC,IF,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
IP 1:50 - 1:200
Protein Name Anti-XPO5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 925-1204 of human XPO5 (NP_065801.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 136.3 kDa
Database Links
Alternative Names XPO5Exportin-5 antibodyExp5 antibodyRan-binding protein 21XPO5 antibodyKIAA1291 antibodyRANBP21
Function Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos), XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form, Proteins containing dsRBDs can associate with this trimeric complex through the RNA, Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins, Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor, XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport, The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus, Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi), Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner
Cellular Localization Nucleus.
Tissue Specificity Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Swiss-Prot Key

 

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