Anti-YWHAE Antibody

Rs. 45,619.00
SKU stj26142

General Information

Product name Anti-YWHAE Antibody
Short Description Rabbit polyclonal to YWHAE
Description This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-YWHAE Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human YWHAE (NP_006752.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 29.2 kDa
Database Links
Alternative Names YWHAE14-3-3 protein epsilon antibody14-3-3EYWHAE
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways, Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif, Binding generally results in the modulation of the activity of the binding partner (By similarity), Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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