Anti-YWHAQ Antibody

Rs. 45,619.00
SKU stj26144

General Information

Product name Anti-YWHAQ Antibody
Short Description Rabbit polyclonal to YWHAQ
Description This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-YWHAQ Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human YWHAQ (NP_006817.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 27.8 kDa
Database Links
Alternative Names YWHAQ14-3-3 protein theta antibody14-3-3 protein T-cell antibody14-3-3 protein tau antibodyProtein HS1YWHAQ
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways, Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif, Binding generally results in the modulation of the activity of the binding partner, Negatively regulates the kinase activity of PDPK1.
Cellular Localization Cytoplasm.
Tissue Specificity Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta, up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (als) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Swiss-Prot Key

 

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