Anti-ZC3HC1 Antibody

Rs. 45,619.00
SKU stj28253

General Information

Product name Anti-ZC3HC1 Antibody
Short Description Rabbit polyclonal to ZC3HC1
Description This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ZC3HC1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZC3HC1 (NP_057562.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 55.3 kDa
Database Links
Alternative Names ZC3HC1Nuclear-interacting partner of ALK antibodyNuclear-interacting partner of anaplastic lymphoma kinase antibodyhNIPA antibodyZinc finger C3HC-type protein 1ZC3HC1 antibodyNIPA antibodyHSPC216
Function Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1), Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase, Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry, May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Cellular Localization Nucleus
Tissue Specificity Widely expressed, highly expressed in heart, skeletal muscle and testis, expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon, weakly or not expressed in leukocytes.
Swiss-Prot Key

 

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