APEX1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-32765

Overview

Synonyms AP endonuclease 1,AP endonuclease class I,AP lyase,APE 1,APE,APE-1,APEN,APEX 1,APEX,APEX nuclease (multifunctional DNA repair enzyme) 1,Apex nuclease 1,APEX nuclease,APEX1,APEX1,Apurinic endonuclease,Apurinic-apyrimidinic endonuclease 1,Apurinic/apyrimidinic (abasic) endonuclease,Apurinic/apyrimidinic endonuclease 1,Apurinic/apyrimidinic exonuclease,APX,BAP1,Deoxyribonuclease (apurinic or apyrimidinic),DNA (apurinic or apyrimidinic site) lyase,DNA-(apurinic or apyrimidinic site) lyase,mitochondrial,EC 4.2.99.18,HAP 1,HAP1,Human Apurinic endonuclease 1,MGC139790,Multifunctional DNA repair enzyme,Redox factor 1,Redox factor-1,REF 1,REF 1 protein,REF-1,REF1,REF1 protein
Swissprot P27695
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of human Ref-1
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation,evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.

 

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