APH1A Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-65068

Overview

Synonyms 6530402N02Rik,AL138795.3,Anterior Pharynx Defective 1,Anterior pharynx defective 1 homolog A,APH 1A,Aph 1alpha,APH-1a,Aph-1alpha,Aph1a,APH1A gamma secretase subunit,APH1A,CGI 78,CGI78,Gamma secretase subunit APH 1A,Gamma Secretase Subunit APH1a,Gamma-secretase subunit APH-1A,Likely ortholog of C. elegans anterior pharynx defective 1A,Presenilin Stabilization Factor,Presenilin-stabilization factor,PSF,UNQ579/PRO1141
Swissprot Q96BI3
Source Rabbit
Reactivity Human
Immunogen A synthetic peptide of human APH1A
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

 

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