ARC Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10826

Overview

Synonyms activity regulated cytoskeleton associated protein,activity regulated gene 3.1 protein homolog,Activity-regulated cytoskeleton-associated protein,Activity-regulated gene 3.1 protein homolog,Arc,ARC/ARG3.1,ARC,Arg3.1
Swissprot Q7LC44
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human ARC
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.5mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.

 

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