ARHGEF11 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-32540

Overview

Synonyms ARHGB,ARHGEF 11,ARHGEF11,DKFZp667F1223,Glutamate transporter EAAT4 associated protein 48,GTRAP 48,GTRAP48,KIAA0380,OTTHUMP00000038716,OTTHUMP00000038717,PDZ RHOGEF,PDZ-RhoGEF,Rho guanine exchange factor (GEF) 11,Rho guanine nucleotide exchange factor (GEF) 11,Rho guanine nucleotide exchange factor 11,RhoA specific guanine nucleotide exchange factor,RhoGEF glutamate transport modulator
Swissprot O15085
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the N-terminal region of human PDZ-RhoGEF
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:5000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

 

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