ASGR1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64528

Overview

Synonyms ASGP-R 1,ASGPR 1,ASGPR,ASGPR1,Asgr1,ASGR1,Asialoglycoprotein receptor 1,C type lectin domain family 4 member H1,C-type lectin domain family 4 member H1,CLEC4H1,Hepatic lectin H1,HL-1
Swissprot P07306
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human ASGR1
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

 

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